Author:
Hamlet A. Bevin,Durst Tony
Abstract
The use of dialkylaminomethyl derivatives as a new β-lactam N—H protecting group is described. The group is stable to basic reagents but is readily removed with dilute aqueous acids. 1-Dialkylaminomethyl derivatives bearing a 4-substituent are converted in good yield and with high stereoselectivity into trans-3,4-disubstituted derivatives via reaction with LDA and subsequent addition of electrophiles. The products of several of these sequences are of interest as intermediates to thienamycin related substances.
Publisher
Canadian Science Publishing
Subject
Organic Chemistry,General Chemistry,Catalysis
Cited by
25 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献