Pseurotin A1 and A2, two new 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-diones from the holothurian-derived fungus Aspergillus fumigatus WFZ-25-Reference-Cited by-同舟云学术

Pseurotin A1 and A2, two new 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-diones from the holothurian-derived fungus Aspergillus fumigatus WFZ-25

Published:2011-01 Issue:1 Volume:89 Page:72-76
ISSN:0008-4042
Container-title:Canadian Journal of Chemistry
language:en
Short-container-title:Can. J. Chem.

Author:

Wang Fa-Zuo¹²,Li De-Hai¹²,Zhu Tian-Jiao¹²,Zhang Min¹²,Gu Qian-Qun¹²

Affiliation:

1. Key Laboratory of Marine Bio-resources Sustainable Utilization, Research Center for Marine Microbes, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, P. R. China.

2. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P. R. China.

Abstract

Two new metabolites containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione core, pseurotin A1 (1) and A2 (2), as well as pseurotin A (3), were isolated from the holothurian-derived fungus Aspergillus fumigatus WFZ-25. These compounds were determined using extensive analysis of their spectroscopic data, including 1D and 2D NMR, HR-ESI-MS, and circular dichroism (CD) experiments.

Publisher

Canadian Science Publishing

Subject

Organic Chemistry,General Chemistry,Catalysis

Link

http://www.nrcresearchpress.com/doi/pdf/10.1139/V10-157

Reference16 articles.

1. Seven new prenylated indole diketopiperazine alkaloids from holothurian-derived fungus Aspergillus fumigatus

2. Isolation and Structure of Pseurotin A, a Microbial Metabolite ofPseudeurotium ovalis STOLK with an Unusual Heterospirocyclic System

3. Pseurotin, a New Metabolite ofPseudeurotium ovalis STOLK Having an Unusual Hetero-Spirocyclic System. (Preliminary Communication)

4. Pseurotin A and 8-O-Demethylpseurotin A fromAspergillus fumigatusand Their Inhibitory Activities on Chitin Synthase

5. The Crystal and Molecular Structure of 12, 13-Dibromopseurotin

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