Affiliation:
1. Institute of Parasitology, McGill University, Macdonald Campus, 21,111 Lakeshore Road, Ste. Anne de Bellevue, QC H9X 3V9, Canada.
Abstract
Parasitic platyhelminths of the genus Schistosoma Weinland, 1858 (Trematoda, Digenea) are the etiological agents of human schistosomiasis, one of the most prevalent and debilitating parasitic diseases worldwide. Praziquantel is the only drug treatment available in most parts of the world and the effectiveness of the drug is threatened by the prospect of drug resistance. There is a pressing need to learn more about the basic biology of this organism and to identify molecular targets for new therapeutic drugs. The nervous system of schistosomes coordinates many activities that are essential for parasite survival, and as such is an attractive target for chemotherapeutic intervention. Until recently, very little was known about the molecular mechanisms of neuronal signaling in these organisms, but this is rapidly changing following the completion of the genome sequence and several recent developments in schistosome transgenesis and gene silencing. Here we review the current status of schistosome neurobiology and discuss prospects for future research as the field moves into a postgenomics era. One of the themes that will emerge from this discussion is that schistosomes have a rich diversity of neurotransmitters and receptors, indicating a more sophisticated system of neuronal communication than might be expected of a parasitic flatworm. Moreover, many of these transmitter receptors share little sequence homology with those of the human host, making them ideally suited for selective drug targeting. Strategies for characterization of these important parasite proteins will be discussed.
Publisher
Canadian Science Publishing
Subject
Animal Science and Zoology,Ecology, Evolution, Behavior and Systematics
Cited by
34 articles.
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