The nuclear receptor subfamily 4 group A1 in human disease

Author:

Wang Hongshuang1ORCID,Zhang Mengjuan1,Fang Fang1,Xu Chang1,Liu Jiazhi1,Gao Lanjun1,Zhao Chenchen1,Wang Zheng23,Zhong Yan23,Wang Xiangting2

Affiliation:

1. Graduate School, Hebei University of Chinese Medicine, Shijiazhuang 050091, China

2. Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns Research, Shijiazhuang 050091, China

3. Institute of Integrative Medicine, College of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang 050200, China

Abstract

Nuclear receptor 4A1 (NR4A1), a member of the NR4A subfamily, acts as a gene regulator in a wide range of signaling pathways and responses to human diseases. Here, we provide a brief overview of the current functions of NR4A1 in human diseases and the factors involved in its function. A deeper understanding of these mechanisms can potentially improve drug development and disease therapy.

Publisher

Canadian Science Publishing

Subject

Cell Biology,Molecular Biology,Biochemistry

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