Photochemical reaction of β-ionone derivatives in the presence of oxygen. A convenient synthesis of substituted 1,2,4-trioxanes

Abstract

This paper describes a simple and convenient method for the preparation of substituted 1,2,4-trioxanes. The scope of the one-pot photooxidation of β-ionones has been extended to include derivatives bearing additional functionalities in the beta-ionone ring. The relative stereochemistry of the products has been established by analysis of 1H and 13C NMR spectra.Key words: 1,2,4-trioxanes, photooxidation, cyclic peroxides, tetrahydrobenzopyranes, antimalarials.