Microwave-assisted regioselective synthesis of acyclic nucleosides through an alkylating reaction with 2-oxa-1,4-butanediol diacetate-Reference-Cited by-同舟云学术

Microwave-assisted regioselective synthesis of acyclic nucleosides through an alkylating reaction with 2-oxa-1,4-butanediol diacetate

Published:2006-05-01 Issue:5 Volume:84 Page:819-824
ISSN:0008-4042
Container-title:Canadian Journal of Chemistry
language:en
Short-container-title:Can. J. Chem.

Author:

Qu Guirong,Han Suhui,Zhang Zhiguang,Geng Mingwei,Xue Feng

Abstract

An efficient and green procedure for the synthesis of purine acyclic nucleosides through microwave-assisted alkylation of various purine nucleobases with 2-oxa-1,4-butanediol diacetate in the absence of solvent and catalyst is described. The advantages of using this method include its environmental friendliness, simple manipulation, short reaction time, high regioselectivity, and good yields.Key words: acyclic nucleosides, microwave irradiation, regioselectivity, alkylation, 2-oxa-1,4-butanediol diacetate.

Publisher

Canadian Science Publishing

Subject

Organic Chemistry,General Chemistry,Catalysis

Link

http://www.nrcresearchpress.com/doi/pdf/10.1139/v06-061

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