Author:
Kutney James P.,Vlattas I.,Rao Ganti Venkat
Abstract
The cyclization of a 9,12-seco-11-nor keto acid in the hecogenin series in the presence of benzylamine and anhydrous ammonia is described. The benzylamine reaction follows an unusual course whereas the ammonia reaction proceeds normally to provide an enol lactam. The sequence represents the first synthesis of an 11-aza derivative in the steroidal sapogenin series.
Publisher
Canadian Science Publishing
Subject
Organic Chemistry,General Chemistry,Catalysis
Cited by
14 articles.
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