The synthesis and high-resolution NMR spectroscopy of ethyl N-(2-triphenylmethylthio)ethanoyl-O-{4′-[4″-(1″-bis(2″′-chloroethyl)amino)phenyl]butanoyl}-L-seryl-S-benzyl-L-cysteine: a chelate–chlorambucil complex for use as a ligand for 99mTc radio-imaging

Abstract

A potential agent for the imaging of tumours has been synthesized from the antineoplastic agent chlorambucil. Standard peptide coupling techniques were used to synthesize a tripeptide covalently coupled to chlorambucil in 10 steps. The final product was characterized by high-resolution NMR spectroscopy. Key words: ethyl N-triphenylmethylthioethanoyl-O-{4′-[4″-(1"-bis(2″′-chloroethyl)amino)phenyl]butanoyl}-L-seryl-S-benzyl-L-cysteine, NMR spectroscopy, synthesis, radio-imaging agent.