Author:
Hill Richard K.,Abächerli Claudio,Hagishita Sanji
Abstract
Beginning with (R)-pulegone, a CD3 group attached to the stereogenic center containing CH3 has been created by conversion to citronellal-1-d, exchange of the acidic hydrogens at C-2 by deuterium, and decarbonylation with Wilkinson's catalyst. Oxidation to isovaleric acid-d3 and conversion to leucine by standard procedures gave the (2S,4S) and (2R,4S) diastereomers (10 and 12) of [5,5,5-2H3]leucine.
Publisher
Canadian Science Publishing
Subject
Organic Chemistry,General Chemistry,Catalysis
Cited by
18 articles.
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