Facile one-pot synthesis of sugar–thiazolidinone derivatives

Author:

Darehkordi Ali1,Saidi Kazem2,Ghazi Somayeh1

Affiliation:

1. Department of Chemistry, Faculty of Science, Vali-e-asr University of Rafsanjan, Rafsanjan 77176, Iran.

2. Department of Chemistry, Shahid Bahonar University of Kerman, Kerman, Iran.

Abstract

A simple, efficient, and cost-effective method for the synthesis of a series of sugar–thiazolidinone derivatives by a one-pot reaction of the corresponding thiosemicarbazone of d-galactose, d-glucose, and d-mannose compounds in the presence of dimethyl or diethyl acetylenedicarboxylate is described. Two different methods were used and high yields were obtained in both cases: (A) in EtOAC–H2O at an ambient temperature and (B) microwave irradiation under solvent-free conditions.

Publisher

Canadian Science Publishing

Subject

Organic Chemistry,General Chemistry,Catalysis

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