Author:
Woodford V. R.,Quan Lillian,Cutts F.
Abstract
An experimental alkaptonuria induced by tryptophan deficiency has been observed in the rat. The condition of alkaptonuria followed development of signs of tryptophan deficiency as judged by weight loss of the young, growing rat and its general appearance. Homogentisic acid was identified by a comparison of its behavior on thin-layer chromatography with authentic homogentisate and by means of the enzyme homogentisic acid oxidase. The condition was relieved by the return of tryptophan to the diet.
Publisher
Canadian Science Publishing
Cited by
2 articles.
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1. Gelenke;Spezielle pathologische Anatomie;1984
2. Effects of ingestion of disproportionate amounts of amino acids.;Physiological Reviews;1970-07