Author:
Hochster R. M.,Nozzolillo C. G.
Abstract
Extracts of Xanthomonas phaseoli (XP8) degrade certain ribonucleosides readily by hydrolytic cleavage of the ribose moiety. Thus, uridine is converted to uracil and ribose, and cytidine to cytosine and ribose, with little deamination to uracil and ammonia taking place. Commercial adenosine is deaminated to inosine and ammonia without further significant cleavage. The data presented permit a choice to be made between the two theoretically possible pathways of guanosine degradation. With chromatographic evidence for xanthine but not for xanthosine and with spectrophotometric evidence for the intermediate formation of guanine, the mechanism of guanosine breakdown is described as being the result of hydrolytic cleavage to guanine and ribose followed by deamination to xanthine and ammonia.
Publisher
Canadian Science Publishing
Subject
Genetics,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Immunology,Microbiology
Cited by
5 articles.
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