Affiliation:
1. Department of Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, ON N2L 3G1, Canada.
Abstract
Carbon–sulfur biological chemistry encompasses a fascinating area of biochemistry and medicinal chemistry and includes the roles that methionine and S-adenosyl-l-methionine play in cells as well as the chemistry of intracellular thiols such as glutathione. This article, based on the 2014 Bernard Belleau Award lecture, provides an overview of some of the key investigations that were undertaken in this area from a bioorganic perspective. The research has ameliorated our fundamental knowledge of several of the enzymes utilizing these sulfur-containing molecules, has led to the development of several novel 19F biophysical probes, and has explored some of the medicinal chemistry associated with these processes.
Publisher
Canadian Science Publishing
Subject
Organic Chemistry,General Chemistry,Catalysis
Reference70 articles.
1. Voet, D.; Voet, J. G. Biochemistry; 4th ed.; John Wiley & Sons, Inc.: Hoboken, NJy, 2011.
2. Ibba, M.; Francklyn, C.; Cusak, S. The Aminoacyl-tRNA Syntetases. Landes Bioscience: Georgetown, TX, 2005.
3. Peptide Deformylase: A New Target in Antibacterial, Antimalarial and Anticancer Drug Discovery
4. N-terminal protein modifications: Bringing back into play the ribosome
5. N‐terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effects
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献