THE PRODUCTION OF ACUTE MASSIVE HEPATIC NECROSIS IN RATS BY DIETARY MEANS

Abstract

Acute hepatic necrosis has been produced in every rat of a group fed a diet low in protein, relatively deficient in the tocopherols, and containing cod liver oil and rancid lard. The evidence suggests that the latter two components have been instrumental in effecting this high incidence of liver necrosis, possibly by means of their well known deleterious action on the tocopherols.