Neat reaction microwave technology for the synthesis of N-substituted-1,4-dihydropyridines

Abstract

Hantzsch synthesis of N-substituted-1,4-dihydropyridines (1,4-DHP) was carried out using an environmentally benign procedure. Neat reactants were subjected to microwave irradiation (MWI) to give the required products in excellent yield. Appreciable results were not obtained when conventional synthesis using neat reactants was carried out. The good yield and rate enhancement observed in the case of microwave irradiation is attributed to the uniform heating effect of microwaves.Key words: 1,4-dihydropyridines (1,4-DHP), microwave irradiation (MWI), neat reaction, solid support.