Preconditioning Prevents Ischemia-Induced Neuronal Death Through Persistent Akt Activation in the Penumbra Region of the Rat Brain-Reference-Cited by-同舟云学术

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Preconditioning Prevents Ischemia-Induced Neuronal Death Through Persistent Akt Activation in the Penumbra Region of the Rat Brain

Published:2004 Issue:5 Volume:66 Page:521-527
ISSN:0916-7250
Container-title:Journal of Veterinary Medical Science
language:en
Short-container-title:The Journal of Veterinary Medical Science

Author:

NAKAJIMA Takayuki¹,IWABUCHI Sadahiro¹,MIYAZAKI Hiroyuki²,OKUMA Yasunobu²,KUWABARA Mikinori³,NOMURA Yasuyuki²,KAWAHARA Koichi¹

Affiliation:

1. Laboratory of Biomedical Control, Research Institute for Electronic Science, Hokkaido University

2. Department of Pharmacology, Graduate School of Pharmaceutical Science, Hokkaido University

3. Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University

Publisher

Japanese Society of Veterinary Science

Subject

General Veterinary

Link

https://www.jstage.jst.go.jp/article/jvms/66/5/66_5_521/_pdf

Reference35 articles.

1. 1. Andjelkovic, M., Jakubowicz, T., Cron, P., Ming, X.-F., Han, J.-W. and Hemmings, B. A. 1996. Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc. Natl. Acad. Sci. U.S.A. 93: 5699-5704.

2. 2. Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J. and Greenberg, M. E. 1999. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 96: 857-868.

3. 3. Cardone, M. H., Roy, N., Stennicke, H. R., Salvesen, G. S., Franke, T. F., Stanbridge, E., Frisch, S. and Reed, J. C. 1998. Regulation of cell death protease caspase-9 by phosphorylation. Science 282: 1318-1321.

4. 4. Chalecka-Franaszek, E. and Chuang, D.-M. 1999. Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. Proc. Natl. Acad. Sci. U.S.A. 96: 8745-8750.

5. 5. Chen, J., Graham, S. H., Zhu, R. L. and Simon, R. P. 1996. Stress proteins and tolerance to focal cerebral ischemia. J. Cereb. Blood Flow Metab. 16: 566-577.

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