Inotropic effects of a single intravenous recommended dose of pimobendan in healthy dogs

Author:

HORI Yasutomo1,TAIRA Hiroto1,NAKAJIMA Yuji1,ISHIKAWA Yusyun1,YUMOTO Yuki1,MAEKAWA Yuya1,OSHIRO Akiko1

Affiliation:

1. School of Veterinary Medicine, Rakuno Gakuen University, 582 Midori-machi, Bunkyodai, Ebetsu, Hokkaido 069-8501, Japan

Publisher

Japanese Society of Veterinary Science

Subject

General Veterinary

Reference23 articles.

1. 1. Asanoi, H., Ishizaka, S., Kameyama, T., Ishise, H. and Sasayama, S. 1994. Disparate inotropic and lusitropic responses to pimobendan in conscious dogs with tachycardia-induced heart failure. J. Cardiovasc. Pharmacol. 23: 268–274.

2. 2. Boswood, A., Häggström, J., Gordon, S. G., Wess, G., Stepien, R. L., Oyama, M. A., Keene, B. W., Bonagura, J., MacDonald, K. A., Patteson, M., Smith, S., Fox, P. R., Sanderson, K., Woolley, R., Szatmári, V., Menaut, P., Church, W. M., O’Sullivan, M. L., Jaudon, J. P., Kresken, J. G., Rush, J., Barrett, K. A., Rosenthal, S. L., Saunders, A. B., Ljungvall, I., Deinert, M., Bomassi, E., Estrada, A. H., Fernandez Del Palacio, M. J., Moise, N. S., Abbott, J. A., Fujii, Y., Spier, A., Luethy, M. W., Santilli, R. A., Uechi, M., Tidholm, A. and Watson, P. 2016. Effect of pimobendan in dogs with preclinical myxomatous mitral valve disease and cardiomegaly: The EPIC study-a randomized clinical trial. J. Vet. Intern. Med. 30: 1765–1779.

3. 3. Fujino, K., Sperelakis, N. and Solaro, R. J. 1988. Sensitization of dog and guinea pig heart myofilaments to Ca2+ activation and the inotropic effect of pimobendan: comparison with milrinone. Circ. Res. 63: 911–922.

4. 4. Hagemeijer, F., Roth, W. and Brand, H. J. 1989. Correlations between the cardiovascular effects of pimobendan and plasma concentrations of the parent compound and of its major active metabolite, UD-CG 212 CL, in patients with congestive heart failure. J. Cardiovasc. Pharmacol. 14 Suppl 2: S57–S64.

5. 6. Häggström, J., Lord, P. F., Höglund, K., Ljungvall, I., Jöns, O., Kvart, C. and Hansson, K. 2013. Short-term hemodynamic and neuroendocrine effects of pimobendan and benazapril in dogs with myxomatous mitral valve disease and congestive heart failure. J. Vet. Intern. Med. 27: 1452–1462.

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