Affiliation:
1. Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus
2. Grodno State Medical University
Abstract
Macroscopic, histological, electron microscopic, microbiological, and immunological methods were used to study the healing of full-thickness skin wounds in laboratory rats under the influence of quercetin and its complex with 2-hydroxypropyl-β-cyclodextrin. It was revealed that under the influence of quercetin, the wound was completely covered with the epidermis almost a day earlier than in the control, and under the influence of a complex with 2-hydroxypropylβ-cyclodextrin 2.2 days earlier (p < 0.02). This was mainly due to the acceleration of marginal epidermization. There was no positive effect on the wound contraction. Quercetin and especially its complex with cyclodextrin had a stimulating effect on the phagocytic and metabolic activity of neutrophils both on the wound surface and in the blood of animals. The bacterial microflora present on the wound surface during healing coincided with the microflora of the intact skin. Neither the quercetin, nor the quercetin-2-hydroxypropyl-β-cyclodextrin significantly affected its composition.
Publisher
Publishing House Belorusskaya Nauka
Reference27 articles.
1. Povzun S. A., Gerasimov S. M., Klochkov N. D., Kovalenko V. I., Rogachev M. V., Rumakin V. P. [et al.]. Pathological anatomy of combat injuries and their complications: textbook. Saint Petersburg, Military-medical Academy, 2002. 179 p. (in Russian).
2. Bank U., Reinhold D., Kunz D., Schulz H. U., Schneemilch C., Brandt W., Ansorge S. Effects of interleukin-6 (IL-6) and transforming growth factor-beta (TGF-beta) on neutrophil elastase release. Inflammation, 1995, vol. 19, no. 1, pp. 83–99. https://doi.org/10.1007/bf01534383
3. Zhiannu K., Baldan M., Molde A. Neglected or improperly treated wounds. Voenno-polevaya khirurgiya. Rabota khirurgov v usloviyakh ogranichennosti resursov vo vremya vooruzhennykh konfliktov i drugikh situatsii nasiliya. Tom 1 [Military field surgery. The work of surgeons in resource-limited settings during armed conflicts and other situations of violence. Vol. 1]. Geneva, 2010, p. 199 (in Russian).
4. Guimarães I., Baptista-Silva S., Pintado M., Oliveira A. L. Polyphenols: A promising avenue in therapeutic solutions for wound care. Applied Sciences, 2021, vol. 11, no. 3, art. 1230. https://doi.org/10.3390/app11031230
5. Tungmunnithum D., Thongboonyou A., Pholboon A., Yangsabai A. Flavonoids and other phenolic compounds from medicinal plants for pharmaceutical and medical aspects : an overview. Medicines (Basel), 2018, vol. 5, no. 3, art. 93. https://doi.org/10.3390/medicines5030093