Analysis of the radiation effect on the activity of thyroid blood transport systems: connection with the features of thyroid status-Reference-Cited by-同舟云学术

Analysis of the radiation effect on the activity of thyroid blood transport systems: connection with the features of thyroid status

Published:2024-07-08 Issue:3 Volume:68 Page:229-237
ISSN:2524-2431
Container-title:Doklady of the National Academy of Sciences of Belarus
language:
Short-container-title:Dokl. Akad. nauk

Author:

Mityukova T. A.¹^ORCID

Affiliation:

1. Institute of Physiology of the National Academy of Sciences of Belarus

Abstract

Thyroid-binding proteins play an important role in regulating thyroid status. However, the question of the radiation effect on the functional state of thyroid blood transport systems remains insufficiently studied. The aim of the work was to assess the indicators of thyroid status and thyroid blood transport in persons exposed to radiation as a result of the Chernobyl accident. The task of the work was also to analyze the results of an oral test for thyroxine pharmacokinetics in patients with thyroid carcinoma who received radioiodine therapy. Screening studies conducted 5−6 years after the Chernobyl accident indicate the radiation effect on the free thyroxine content in the blood and the functional activity of thyroid protein transport in children and adolescents living in the territories of the Khoiniki district of the Gomel region. The dose-dependent effect of an absorbed dose of 131I was also detected in children and adolescents displaced from the 30 km zone of the Chernobyl accident. The results of an oral test for thyroxine pharmacokinetics demonstrate an increase in the free T4 content against the background of a stable total T4 fraction in patients with thyroid carcinoma who received high dose loads as a result of radioiodine therapy. The conducted studies confirm the possibility of the influence of a high dose of 131I on thyroid blood transport systems and on the ratio of free and bound fractions of thyroid hormones in the blood.

Publisher

Publishing House Belorusskaya Nauka

Reference14 articles.

1. Pappa T., Ferrara A. M., Refetoff S. Inherited defects of thyroxine-binding proteins. Best Practice and Research Clinical Endocrinology and Metabolism, 2015, vol. 29, no. 5, pp. 735–747. https://doi.org/10.1016/j.beem.2015.09.002

2. Feldt-Rasmussen U., Rasmussen Å. Thyroid Hormone Transport and Actions. Diseases of the Thyroid in Childhood and Adolescence, 2007, vol. 11, pp. 80–103. https://doi.org/10.1159/000098021

3. Matveenko I. I., Zyukova O. M., Germenchuk M. G. Dynamics of the radiation and rehabilitation of the environment of the Republic of Belarus territory after the catastrophe in Chernobyl NPP. Nuclear and hazardous waste management Spectrum’94. Atlanta, GA, Illions, 1994, pp. 2419–2424.

4. Gavrilin Yu. I., Gordeev K. I., Ivanov V. K., Ilin L. A., Kondrusev A. I., Margulis U. I., Stepanenko V. F., Khrushch V. T., Shinkarev S. M. Characteristics and results of the determination of the doses of internal irradiation of the thyroid gland in the population of contaminated districts of the Republic of Belarus. Vestnik Rossiiskoi Akademii Meditsinskikh Nauk = Annals of the Russian Academy of Medical Sciences, 1992, no. 2, pp. 35–42 (in Russian).

5. Dunn J. T., Crutchfield H. E., Gutekunst R., Dunn A. D. Methods for measuring iodine in urine. Thyroid, 1993, vol. 3, no. 2, pp. 119–123.