Affiliation:
1. Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus
2. Scientific-Practical Materials Research Center, National Academy of Sciences of Belarus
3. Institute for Nuclear Problems, Belarusian State University
4. Vitebsk State Order of Peoples’ Friendship Medical University
5. B.I. Stepanov Institute of Physics, National Academy of Sciences of Belarus
6. Institute of Physiology, National Academy of Sciences of Belarus
Abstract
In order to therapeutically destroy neoplasms, chemotherapy or radiotherapy is usually applied, and in isotope medicine short-lived radionuclides are injected into the tumor (59Fe, 90Y, 95Zr, 99mTc, 106Ru, 114*In, 147Eu, 148Eu, 155Eu, 170Tm, 177mLu, 188Re, 210Po, 222Rn, 230U, 237Pu, 240Cm, 241Cm, 253Es). Binary (or neutron capture) therapy is a technology designed to selectively treat malignant tumors and using drugs tropic to tumors containing non-radioactive nuclides (10B, 113Cd, 157Gd at al.). Triadic therapy is the sequential introduction into the body of a combination of two or more separately inactive and harmless components, tropic to tumor tissues and capable of selectively accumulating in them or entering into chemical interaction with each other and destroying tumor neoplasms under certain sensitizing external influences. The aim of this work is to quantum-chemically simulate the electronic structure and to analyze the thermodynamic stability of new doxorubicino-fullerenol agents for the treatment of tumor neoplasms. The need for preliminary studies on the modeling of such objects is due to the extremely high labor intensity, cost and complexity of their practical production.
Publisher
Publishing House Belorusskaya Nauka
Subject
Inorganic Chemistry,Organic Chemistry,Chemistry (miscellaneous),Analytical Chemistry
Cited by
1 articles.
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