Synthesis and study of the effect of arginine-vasopressin (6-9) analogue on the behavior of rats of different ages-Reference-Cited by-同舟云学术

Synthesis and study of the effect of arginine-vasopressin (6-9) analogue on the behavior of rats of different ages

Published:2021-02-10 Issue:1 Volume:57 Page:61-69
ISSN:2524-2342
Container-title:Proceedings of the National Academy of Sciences of Belarus, Chemical Series
language:
Short-container-title:Vescì Akademìì navuk Belarusì. Seryâ himičnyh navuk

Author:

Borodina K. V.¹,Stakhanova A. A.²,Martinovich V. P.¹,Voskresenskaya O. G.²,Golubovich V. P.¹,Kamensky A. A.²

Affiliation:

1. Institute of Bioorganic Chemistry of the National Academy of Science of Belarus

2. M.V. Lomonosov Moscow State University, Biological Faculty

Abstract

The article presents the synthesis and results of the study of the effect of chronic neonatal administration by intranasal method of an analogue of the C-terminal fragment of arginine-vasopressin (AVP) - N-Ac-DMet-Pro-Arg-Gly-NH2 on the training and level of depression in white rats of three age groups. It is shown that the most significant effect of the analogue was manifested in the test for the development of conditional reaction of active avoidance. A favorable effect on the degree of depression of animals is also well expressed. According to the data obtained, we conclude that the action of the peptide is manifested only under the influence of a biologically significant stimulus.

Publisher

Publishing House Belorusskaya Nauka

Subject

Inorganic Chemistry,Organic Chemistry,Chemistry (miscellaneous),Analytical Chemistry

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Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. THE EFFECT OF THE AC-D-MPRG PEPTIDE BASED ON THE C-TERMINAL FRAGMENT OF ARGININE-VASOPRESSIN(6-9) ON THE CHARACTER OF RATS OF DIFFERENT AGES;Vestnik Moskovskogo universiteta. Seria 16. Biologia;2023-07-12

2. Synthesis and Investigation of the Antidepressant Properties of Novel Analogs of Arginine-Vasopressin;Russian Journal of Bioorganic Chemistry;2022-06