An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein-Reference-Cited by-同舟云学术

An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein

Published:2018-01 Issue:1 Volume:293 Page:47-68
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Glidden Michael D.,Aldabbagh Khadijah,Phillips Nelson B.,Carr Kelley,Chen Yen-Shan,Whittaker Jonathan,Phillips Manijeh,Wickramasinghe Nalinda P.,Rege Nischay,Swain Mamuni,Peng Yi,Yang Yanwu,Lawrence Michael C.,Yee Vivien C.,Ismail-Beigi Faramarz,Weiss Michael A.

Funder

National Institutes of Health

American Diabetes Association

Juvenile Diabetes Research Foundation International

National Health and Medical Research Council

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference103 articles.

1. The structure of 2Zn pig insulin crystals at 1.5 Å resolution;Baker;Philos. Trans. R. Soc. Lond. B Biol. Sci,1988

2. Pursuit of a perfect insulin;Zaykov;Nat. Rev. Drug Discov,2016