Multiple Conformers in Active Site of Human Dihydrofolate Reductase F31R/Q35E Double Mutant Suggest Structural Basis for Methotrexate Resistance-Reference-Cited by-同舟云学术

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Multiple Conformers in Active Site of Human Dihydrofolate Reductase F31R/Q35E Double Mutant Suggest Structural Basis for Methotrexate Resistance

Published:2009-07 Issue:30 Volume:284 Page:20079-20089
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Volpato Jordan P.,Yachnin Brahm J.,Blanchet Jonathan,Guerrero Vanessa,Poulin Lucie,Fossati Elena,Berghuis Albert M.,Pelletier Joelle N.

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference45 articles.

1. Metastatic osteosarcoma

2. Radiochemotherapy with Vinblastine, Methotrexate, and Bleomycin in the treatment of verrucous carcinoma of the head and neck

3. Use of methotrexate in juvenile idiopathic arthritis

4. Functional analysis of altered reduced folate carrier sequence changes identified in osteosarcomas

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1. In silico screening of inhibitors against human dihydrofolate reductase to identify potential anticancer compounds;Journal of Biomolecular Structure and Dynamics;2023-03-08

2. Simultaneous fluorescence imaging of Golgi O2•− and Golgi H2O2 in mice with hypertension;Biosensors and Bioelectronics;2022-10

3. Massively parallel, computationally guided design of a proenzyme;Proceedings of the National Academy of Sciences;2022-04-04

4. Simultaneous Fluorescence Imaging of Golgi O2•− and Golgi H2o2 in Mice with Hypertension;SSRN Electronic Journal;2022

5. Structural Insights of Three 2,4-Disubstituted Dihydropyrimidine-5-carbonitriles as Potential Dihydrofolate Reductase Inhibitors;Molecules;2021-05-29

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