Rational design, synthesis, and evaluation of uncharged, “smart” bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase-Reference-Cited by-同舟云学术

Rational design, synthesis, and evaluation of uncharged, “smart” bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase

Published:2020-03 Issue:13 Volume:295 Page:4079-4092
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Gorecki Lukas,Gerlits Oksana,Kong Xiaotian,Cheng Xiaolin,Blumenthal Donald K.^ORCID,Taylor Palmer^ORCID,Ballatore Carlo^ORCID,Kovalevsky Andrey^ORCID,Radić Zoran^ORCID

Funder

HHS NIH NIH Office of the Director

University of California San Diego Academic Senate

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference28 articles.

1. A powerful reactivator of alkylphosphate-inhibited acetylcholinesterase;Wilson;Biochim. Biophys. Acta,1955

2. Protection by oximes of bis-pyridinium ions against lethal diisopropyl phosphonofluoridate poisoning;Hobbiger;Nature,1958

3. Toxogonin in sarin, soman and tabun poisoning;Heilbronn;Biochem. Pharmacol,1965

4. Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators;Pang;Chem. Biol,2003

5. Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates;Ekström;Biochem. Pharmacol,2006

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4. Progress on the Development of Oxime Derivatives as a Potential Antidote for Organophosphorus Poisoning;Frontiers in Clinical Drug Research - CNS and Neurological Disorders;2024-03-10

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