Insinuating cocktailed components in biocompatible-nanoparticles could act as an impressive neo-adjuvant strategy to combat COVID-19

Abstract

The novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spread rapidly worldwide, freezes all sectors, and was declared a life-threatening disease by the World Health Organization on Jan 30, 2020. So far, no specific drugs are identified or approved for treating SARS-CoV-2. In the past few years, nanomaterials are in the limelight for their ability to deliver the drugs effectively and selectively to target like siRNA, the prime infection sites, and benefiting us to visualize the particular regions, treatment reactions via non-intruding imaging techniques. As intranasal delivery interacts directly to the infection site with minimal side effects on the healthy cell, we postulate to administer a mixture of few polyherbal formulations like the golden spice curcumin, sitopaladi churna (SPC), and kaempferol in zein-chitosan nanoparticles as a life-saving measure for treating Coronavirus disease (COVID-19) cases. This viewpoint will shed light on the antiviral role of curcumin, SPC, and kaempferol zein-chitosan nanoparticle to modulate immune responses and observe its curative approach to the current pandemic COVID.