Affiliation:
1. University of California Irvine
2. University of Southern California
Abstract
Photo-sono therapy (PST) is an innovative anti-vascular approach based
on cavitation-induced spallation. Currently, passive cavitation
detection (PCD) is the prevalent technique for cavitation monitoring
during treatment. However, the limitations of PCD are the lack of
spatial information of bubbles and the difficulty of integration with
the PST system. To address this, we proposed a new, to the best of our
knowledge, cavitation mapping method that integrates Doppler optical
coherence tomography (OCT) with PST to visualize bubble dynamics in
real time. The feasibility of the proposed system has been confirmed
through experiments on vascular-mimicking phantoms and in vivo rabbit
ear vessels, and the results are compared to high-speed camera
observations and PCD data. The findings demonstrate that Doppler OCT
effectively maps cavitation in real time and holds promise for guiding
PST treatments and other cavitation-related clinical applications.
Funder
National Institute of
Health
Air Force Office of Scientific
Research
Cited by
1 articles.
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