Frondoside A from sea cucumber and nymphaeols from Okinawa propolis: Natural anti-cancer agents that selectively inhibit PAK1 in vitro
Author:
Affiliation:
1. PAK Research Center, University of the Ryukyus
2. Department of Food and Nutritional Sciences, University of Shizuoka
3. PAK Research Center
Publisher
International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)
Subject
Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics,General Medicine
Link
https://www.jstage.jst.go.jp/article/ddt/11/2/11_2017.01011/_pdf
Reference13 articles.
1. 1. Demestre M, Messerli SM, Celli N, Shahhossini M, Kluwe L, Mautner V, Maruta H. CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice. Phytother Res. 2009; 23:226-230.
2. 2. Messerli SM, Ahn MR, Kunimasa K, Yanagihara M, Tatefuji T, Hashimoto K, Mautner V, Uto Y, Hori H, Kumazawa S, Kaji K, Ohta T, Maruta H. Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice. Phytother Res. 2009; 23:423-427.
3. 3. Maruta H. Herbal therapeutics that block the oncogenic kinase PAK1: A practical approach towards PAK1-dependent diseases and longevity. Phytother Res. 2014; 28:656-672.
4. 4. Tsuchiya I, Hosoya T, Ushida M, Kunimasa K, Ohta T, Kumazawa S. Nymphaeol-A isolated from Okinawan propolis suppresses angiogenesis and induces caspasedependent apoptosis via inactivation of survival signals. Evid Based Complement Alternat Med. 2013; 2013:826245.
5. 5. Kumazawa S, Murase M, Momose N, Fukumoto S. Analysis of antioxidant prenylflavonoids in different parts of Macaranga tanarius, the plant origin of Okinawan propolis. Asian Pac J Trop Med. 2014; 7:16-20.
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