High prevalence of <i>VKORC1*3</i> (G9041A) genetic polymorphism in north Indians: A study on patients with cardiac disorders on acenocoumarol-Reference-Cited by-同舟云学术

High prevalence of VKORC1*3 (G9041A) genetic polymorphism in north Indians: A study on patients with cardiac disorders on acenocoumarol

Published:2015 Issue:6 Volume:9 Page:404-410
ISSN:1881-7831
Container-title:Drug Discoveries & Therapeutics
language:en
Short-container-title:DD&T

Author:

Sehgal Tushar¹,Hira Jasbir Kaur¹,Ahluwalia Jasmina¹,Das Reena¹,Vijayvergiya Rajesh²,Rana Sandip Singh³,Varma Neelam¹

Affiliation:

1. Department of Hematology, Postgraduate Institute of Medical Education and Research

2. Department of Cardiology, Postgraduate Institute of Medical Education and Research

3. Department of Cardiovascular and Thoracic Surgery, Postgraduate Institute of Medical Education and Research

Publisher

International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics,General Medicine

Link

https://www.jstage.jst.go.jp/article/ddt/9/6/9_2015.01066/_pdf

Reference27 articles.

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2. 2. Leung AY, Chow HC, Kwong YL, Fung AT, Chow WH, Yip AS, Liang R. Genetic polymorphism in exon 4 of cytochrome P450 CYP2C9 may be associated with warfarin sensitivity in Chinese patients. Blood 2001; 98:2584-2587.

3. 3. Bodin L, Verstuyft C, Tregouet DA, Robert A, Dubert L, Funck-Brentano C, Jaillon P, Beaune P, Laurent-Puig P, Becquemont L, Loriot MA. Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity. Blood. 2005; 106:135-140.

4. 4. Wolf CR, Smith G. Pharmacogenetics. Br Med Bull. 1999; 55:366-386.

5. 5. Thijssen HH, Flinois JP, Beaune PH. Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes. Drug Metab Dispos. 2000; 28:1284-1290.

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