MiR-15a-5p regulates viability and matrix degradation of human osteoarthritis chondrocytes via targeting VEGFA
Author:
Affiliation:
1. Department of Orthopedics, Yiwu Central Hospital Affiliated to Wenzhou Medical University
2. Department of Orthopedic Trauma, Peking University Third Hospital
Publisher
International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine,Health(social science)
Link
https://www.jstage.jst.go.jp/article/bst/10/6/10_2016.01187/_pdf
Reference28 articles.
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2. 2. Cui X, Wang S, Cai H, Lin Y, Zheng X, Zhang B, Xia C. Overexpression of microRNA-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting PIK3R1. Sci Rep. 2016; 6:23117.
3. 3. Matsukawa T, Sakai T, Yonezawa T, Hiraiwa H, Hamada T, Nakashima M, Ono Y, Ishizuka S, Nakahara H, Lotz MK, Asahara H, Ishiguro N. MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes. Arthritis Res Ther. 2013; 15:R28.
4. 4. Zelzer E, Mamluk R, Ferrara N, Johnson RS, Schipani E, Olsen BR. VEGFA is necessary for chondrocyte survival during bone development. Development. 2004; 131:2161-2171.
5. 5. Hamilton JL, Nagao M, Levine BR, Chen D, Olsen BR, Im HJ. Targeting VEGF and Its Receptors for the Treatment of Osteoarthritis and Associated Pain. J Bone Miner Res. 2016; 31:911-924.
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