Oxygen-ozone therapy in musculoskeletal disorders: a narrative review

Author:

de Sire Alessandro1,Lippi Lorenzo2,Invernizzi Marco2

Affiliation:

1. Physical and Rehabilitative Medicine Unit, Dept of Medical and Surgical Sciences, Uni. Catanzaro IT

2. Physical and Rehabilitative Medicine, Dept of Health Sciences, University of Eastern Piedmont IT

Abstract

Oxygen-ozone (O2O3) therapy is a spreading intervention proposed to reduce pain intensity and improve physical function in patients with musculoskeletal conditions. The biological effects of O2O3 are strictly related to its biochemical properties. It induces moderate oxidative stress and promotes the activation of specific transcriptional pathways related to endogenous radical scavengers. In this context, O2O3 therapy promotes immune modulation and inflammatory regulation that might potentially have a key role in the management of patients with musculoskeletal disorders. Interestingly, in recent years a growing number of studies have been showing promising results of O2O3 local therapy in different conditions, including low back pain, neck pain, knee osteoarthritis, and temporomandibular disorders. Due to its positive effects in terms of not only pain management but also functional improvement, it has been suggested that this promising therapy might be effectively integrated into a comprehensive rehabilitation approach to musculoskeletal disorders. Despite these considerations, several questions remain open about the effects of O2O3 combined with other conventional approaches. The aim of this narrative review was therefore to summarize the state of the art of O2O3 local therapy from a rehabilitation perspective, underlining its potential synergisms with other techniques in a multitarget rehabilitation approach to musculoskeletal disorders.

Publisher

Medimay Communication

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3