Affiliation:
1. Department of Cardiac MR, Fuwai Hospital, National Center for Cardiovascular Diseases of China, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, 100037 Beijing, People’s Republic of China
Abstract
Objective: We aimed to evaluate the diagnostic performance of three-dimensional whole-heart magnetic resonance coronary angiography (MRCA) in detecting coronary artery disease (CAD) with invasive coronary angiography as the reference standard.Methods: We searched PubMed
and Embase for studies evaluating the diagnostic performance of three-dimensional whole-heart MRCA for the diagnosis of CAD with invasive coronary angiography as the reference standard. The bivariate mixed-effects regression model was applied to synthesize available data. The clinical utility
of whole-heart MRCA was calculated by the posttest probability based on Bayes’s theorem.Results: Eighteen studies were included, of which 16 provided data at the artery level. Patient-based analysis revealed a pooled sensitivity of 0.90 (95% confidence interval [CI] 0.87‐0.93)
and specificity of 0.79 (95% CI 0.73‐0.84), while the pooled estimates were 0.86 (95% CI 0.82‐0.89) and 0.89 (95% CI 0.84‐0.92), respectively, at the artery level. The areas under the summary receiver operating characteristic curve were 0.93 (95% CI 0.90‐0.95) and
0.92 (95% CI 0.90‐0.94) at the patient and artery levels, respectively. With a pretest probability of 50%, the patients’ posttest probabilities of CAD were 81% for positive results and 11% for negative results.Conclusions: Whole-heart MRCA can be an alternative noninvasive
method for diagnosis and assessment of CAD.