Affiliation:
1. Department of Psychiatry, Symbiosis Medical College for Women (SMCW), Symbiosis International (Deemed University) (SIU), Lavale, Pune, Maharashtra, India
Abstract
Neuroleptic malignant syndrome (NMS) is a serious side effect of antipsychotic drugs. Alcohol withdrawal delirium and NMS can present with similar symptoms and hence can create confusion. We present a case of a young male who had no underlying medical illness except alcohol use disorder but developed NMS with a single dose of haloperidol (5 mg) in withdrawal delirium state. Alcohol has been reported to cause polymorphism in the D2 dopamine receptors, which is also the site of action for antipsychotic medicines. Apart from this, dehydration, physical exhaustion, and restraint use may have increased the risk of NMS in our patient. We managed both the conditions, alcohol withdrawal delirium and NMS, simultaneously with lorazepam and bromocriptine.
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