Genetic Insights and Genetic Predisposition of Osteoporosis – A Systematic Review

Abstract

Abstract Osteoporosis (OP) is a condition characterized by fragile and easily broken bones, impacting around 200 million individuals worldwide. OP is defined by reduced bone mineral density (BMD) and deterioration of bone microarchitecture, both of which greatly heighten the likelihood of fractures. It is now widely recognized that OP is a complex condition resulting from the interplay between genetic factors and environmental influences. Identification of markers with a genetic predisposition to OP is crucial in the development of disease prevention. In the recent past, the scientific community has concentrated on understanding the genetic basis of OP. This review focuses on genetic insights of OP and different gene polymorphisms associated with BMD and OP. Molecular screening of individuals could be useful to identify susceptibility genes of OP for better individualized clinical management of the disease.