Qualitative and Quantitative Electrocardiogram Parameters in a Large Cohort of Children with Duchenne Muscle Dystrophy in Comparison with Age-Matched Healthy Subjects: A Study from South India

Author:

Girija Manu S.1,Menon Deepak1,Polavarapu Kiran12,Preethish-Kumar Veeramani1,Vengalil Seena1,Nashi Saraswati1,Keertipriya Madassu1,Bardhan Mainak1,Thomas Priya T.3,Kiran Valasani R.1,Nishadham Vikas1,Sadasivan Arun3,Huddar Akshata1,Unnikrishnan Gopi K.1,Inbaraj Ganagarajan4,Krishnamurthy Arjun5,Kramer Boris W.6,Sathyaprabha Talakad N.4,Nalini Atchayaram1

Affiliation:

1. Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India

2. Division of Neurology, Department of Medicine, Children’s Hospital of Eastern Ontario Research Institute, The Ottawa Hospital, Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada

3. Department of Psychiatric Social Work, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India

4. Department of Neurophysiology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India

5. Department of Computer Sciences, School of Engineering, Dayananda Sagar University, Bengaluru, Karnataka, India

6. Department of Paediatrics, School of Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands

Abstract

Background: Electrocardiography (ECG) remains an excellent screening tool for cardiac assessment in Duchenne muscular dystrophy (DMD), but an accurate interpretation requires comparison with age-matched healthy controls. Objective: We examined various ECG parameters in children with DMD, in comparison with age-matched controls. Methods: Standard 12-lead ECG tracings of serial patients were screened for quality and selected. Controls were healthy, age-matched school-going children. Both quantitative and qualitative ECG parameters were analyzed. Results: After screening, ECGs from 252 patients with DMD (8.32 ± 3.12 years, 2–21 years) and ECGs from 151 age-matched healthy controls (9.72 ± 2.23, 4–19 years) were included. A significantly higher heart rate, shorter R–R interval, and taller R wave in V1 were seen across all age group of DMD in comparison to controls, with the difference increasing with age. While QT prolongation was seen in all age groups of DMD, QTc prolongation was seen only at 10 years or more. Incomplete right bundle branch block (RBBB) and pathological Q waves in inferolateral leads were exclusive in DMD, with the latter declining with age. Evidence for left ventricular (LV) pathology, such as tall R in V5/V6, increase in SV1 + RV6 height, and QRS complex duration, were seen only in the age group of 10 years or more. Conclusion: Stratification based on age and comparison with age-matched healthy subjects showed that several ECG parameters were influenced by age, and it also identified age-dependent evidence for LV pathology and QTc prolongation in DMD.

Publisher

Medknow

Reference23 articles.

1. Duchenne muscular dystrophy: The heart of the matter;Shih;Curr Heart Fail Rep,2020

2. Improvement of survival in Duchenne muscular dystrophy: Retrospective analysis of 835 patients;Passamano;Acta Myol,2012

3. Diagnosis and management of Duchenne muscular dystrophy, part 2: Respiratory, cardiac, bone health, and orthopaedic management;Birnkrant;Lancet Neurol,2018

4. [Chronologic study of signs of myocardiopathy in progressive muscular dystrophy];Barona Zamora;An Esp Pediatr,1993

5. Re-examination of the electrocardiogram in boys with Duchenne muscular dystrophy and correlation with its dilated cardiomyopathy;Thrush;Am J Cardiol,2009

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