Association of genetic polymorphism in orthodontically induced external apical root resorption- “A Narrative Review”

Abstract

ABSTRACT Orthodontically induced external apical root resorption (OIEARR) is a common complication associated with orthodontic treatment, with genetic factors playing a significant role in its etiology. This article aimed to review the available literature on OIEARR and it is association with genetic polymorphisms. Various electronic databases were searched for cross-sectional, prospective, and retrospective longitudinal studies, randomized controlled trials, and reviews and meta-analyses to determine the impact of genetic polymorphism and OIEAAR only the articles available in English-language were included in the study. In conclusion, this narrative review provides evidence supporting the role of genetic polymorphisms in the susceptibility to OIEARR during orthodontic treatment, highlighting the importance of personalized treatment approaches and genetic screening in orthodontic practice. This revealed a significant association with specific genetic polymorphisms and the susceptibility to OIEARR. Further studies incorporating larger sample sizes and diverse populations are warranted to validate these findings and facilitate the development of targeted interventions for preventing or minimizing OIEARR in orthodontic patients.