Affiliation:
1. Department of Food Science and Nutrition, Faculty of Applied Sciences, UCSI University, Cheras, Kuala Lumpur, Malaysia
2. Secretariat of International Society for Mangrove Ecosystems, Faculty of Agriculture, University of the Ryukyus, Okinawa, Japan
3. School of Foundation Studies, Xiamen University Malaysia, Sepang, Selangor, Malaysia
Abstract
Abstract
The rich chemical constituents and diverse pharmacological properties of Ramulus Mori (RM) or the twig of Morus alba with evidence supported by clinical trials and patents are reviewed. Known as Sangzhi in Chinese, RM is widely used in traditional Chinese medicine to treat gout, arthritis, and rheumatism. Chemical constituents include flavonoids, benzofurans, alkaloids, stilbenes, chalcones, phenolic acids, and coumarins. Bioactivities of RM include antidiabetic, anti-obesity, anti-inflammatory, antityrosinase, neuroprotective, antioxidant, hepatoprotective, cytoprotective, renoprotective, antihyperuricemic, analgesic, antifungal, DNA protective, anticancer, gastroprotective, cardioprotective, anti-hair aging, anti-arthritic, and antiplatelet aggregation properties. The most active compounds from RM are mulberrin, oxyresveratrol, and mulberroside A. All four clinical trials on RM are focused on the treatment of diabetes. The patents entail using RM extracts as cosmetics for skin whitening and as agents for hypoglycemia. Topics for further research on RM are suggested.
Reference83 articles.
1. Phytochemistry, pharmacology, and clinical trials of Morus alba;Chan;Chin J Nat Med,2016
2. Morus alba L. Plant: Bioactive compounds and potential as a functional food ingredient;Chen;Foods,2021
3. Inhibitory effects of Ramulus Mori extracts on melanogenesis;Lee;J Cosmet Sci,2003
4. Rapid analysis of morusin from Ramulus Mori by HPLC-DAD, its distribution in vivo and differentiation in the cultivated mulberry species;Ma;Food Nutr Sci,2013
5. UV irradiation and salicylic acid immersion enhance the level of Mulberroside A in isolated mulberry branches - A huge amount of agro-waste;Wang;Waste Biomass Valorization,2017