Formulation and evaluation of new herbal nutraceutical tablet for the treatment of diabetes mellitus

Abstract

Abstract BACKGROUND: Herbal nutraceutical dosage forms a dietary supplement that improves various chronic diseases. This study aimed to formulate and evaluate new herbal nutraceutical tablets and assess antihyperglycemic and antihyperlipidemia effects in ob/ob mice. METHODS: A herbal nutraceutical tablet was prepared by the wet granulation method. Proximate composition was determined by the Association of Official Analytical Chemists methods. The high-performance liquid chromatography method was used for the estimation of water-soluble vitamins and fat-soluble vitamins. An atomic absorption spectrophotometer was used for analyzing trace elements. Oral glucose tolerance tests and biochemicals were analyzed to assess antihyperglycemic and antihyperlipidemia effects in ob/ob mice. RESULTS: Herbal nutraceutical tablet contains a good amount of energy. Iron, sodium, potassium, phosphorus, magnesium, iodine, copper, zinc, and calcium were present in the newly formulated herbal tablets. A reasonable amount of water-soluble and fat-soluble vitamins were also present. Administration of newly developed herbal nutraceutical tablets (200 mg/kg) in ob/ob mice significantly improved the antihyperglycemic and antihyperlipidemia effects compared to the standard drug metformin (200 mg/kg). CONCLUSIONS: Based on these findings, a newly formulated herbal nutraceutical tablet may be recommended as a dietary supplement and can be utilized as an active type 2 diabetes drug.