Comparison of efficacy and safety of three different concentrations of ropivacaine for labor pain management using patient-controlled epidural analgesia (PCEA): A double-blind, randomized controlled trial

Author:

Bihani Pooja1,Vyas Medha2,Soni Shikha1,Jaju Rishabh3,Janweja Sarita1,Choudhary Usha4

Affiliation:

1. Department of Anaesthesiology, Dr. S. N. Medical College, Jodhpur, Rajasthan, India

2. Department of Anaesthesiology, St. John’s Medical College and Hospital, Bengaluru, Karnataka, India

3. Department of Anaesthesiology, All India Institute of Medical Sciences, Deoghar, Jharkhand, India

4. Department of Anaesthesiology, Medical College, Dholpur, Rajasthan, India

Abstract

Abstract Background and Aims: Labor pain is consistently ranked high on the various pain rating scales, when compared to other painful life experiences, and the experience of labor during the process of childbirth is both complex and subjective. Though patient-controlled epidural analgesia (PCEA) using dilute concentrations of local anesthetics (LAs) has been a popular method to control labor pain, yet the optimal dose and regimen for PCEA remain ambiguous. So, the present study was undertaken to evaluate the safety and efficacy of three different concentrations of ropivacaine for labor analgesia using PCEA. Materials and Methods: Seventy-five healthy nulliparous women who gave voluntary consent for labor analgesia using PCEA were randomly assigned to three groups to receive three different ropivacaine concentrations (0.0625%, 0.1%, and 0.125%) with adjuvant fentanyl 2 μg/ml, after double-blinding. Analgesic efficacy, neuraxial blockade, vital parameters, neonatal outcomes, maternal satisfaction, and side effects were assessed. Primary outcome was total dose of ropivacaine consumed in milligrams. Results: Number of pain breakthroughs (Visual Analog Score >4) and PCEA demand and rescue boluses were found to be statistically more in group 0.0625% (P < 0.01), followed by group 0.1% and were the least in 0.125%. Still, total drug consumed in milligrams was significantly less in 0.0625% group. Maternal satisfaction was comparable among the three groups (P = 0.33). There was no significant difference in maternal side effects and neonatal APGAR scores among the three groups. Conclusion: When three different concentrations of ropivacaine, that is, 0.0625%, 0.1%, and 0.125%, are used for labor analgesia, the use of 0.125% ropivacaine leads to higher total amount of ropivacaine consumed. Despite the lower efficacy in terms of breakthrough pain episodes observed with a 0.0625% ropivacaine concentration for labor analgesia, maternal satisfaction remained consistent across all three doses of ropivacaine. PCEA demand and rescue boluses for the lowest concentration, that is, 0.0625%; and did not affect maternal satisfaction with the management of labor pain.

Publisher

Medknow

Reference21 articles.

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2. Neuraxial techniques of labour analgesia;Gupta;Indian J Anaesth,2018

3. Recent updates in obstetric analgesia;Beg;Indian J Pain,2021

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5. The optimal concentration of bupivacaine and levobupivacaine for labor pain management using patient-controlled epidural analgesia:A double-blind, randomized controlled trial;Baliuliene;Int J Obstetr Anesth,2018

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