A case of myelodysplastic syndrome with t(10;18)(q26;q21)-Reference-Cited by-同舟云学术

A case of myelodysplastic syndrome with t(10;18)(q26;q21)

Published:2019-10 Issue:04 Volume:11 Page:382-384
ISSN:0974-2727
Container-title:Journal of Laboratory Physicians
language:en
Short-container-title:J Lab Physicians

Author:

Ohba Yusuke¹,Yamada-Fujiwara Minami²³,Minagawa Tadanori⁴,Watanabe Suguru⁴,Okitsu Yoko⁵⁶,Izumi Yoshihiko¹,Kameoka Junichi²,Takahashi Shinichiro¹⁶

Affiliation:

1. Department of Clinical Laboratory, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan

2. Department of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan

3. Division of Blood Transfusion and Cell Therapy, Tohoku University Hospital, Sendai, Japan

4. Department of Cardiovascular Surgery, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan

5. Department of Blood Transfusion, Tohoku Medical and Pharmaceutical University, Sendai, Japan

6. Division of Laboratory Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan

Abstract

AbstractAn 82-year-old male was admitted. Pancytopenia, a slightly low white blood cell count (3400/μL), and low levels of red blood cells (2.65 × 106/μL), hemoglobin (10.4 g/dL), and platelets (118,000/μL) were observed. Bone marrow aspiration was performed, revealing hypocellular bone marrow and normal blast levels (0.6%) with no dysplasia. G-banding chromosome analysis revealed the karyotype 45,X,-Y[3]/45, idem, t(10;18)(q26;q21)[13]/46,XY[4]. The patient was diagnosed with myelodysplastic syndrome, unclassified (MDS–U). This is the first case report demonstrating a patient with the chromosomal translocation, t(14;18)(q32;q21), which is extremely rare. This chromosomal aberration was critical for the diagnosis of MDS in this patient.

Publisher

Georg Thieme Verlag KG

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.4103/JLP.JLP_61_19.pdf

Reference10 articles.