KS900: A hypoxia-directed, reductively activated methylating antitumor prodrug that selectively ablates O6-alkylguanine-DNA alkyltransferase in neoplastic cells

Author:

Baumann Raymond P.,Ishiguro Kimiko,Penketh Philip G.,Shyam Krishnamurthy,Zhu Rui,Sartorelli Alan C.

Funder

U.S. Public Health Service

National Cancer Institute

National Foundation for Cancer Research

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference39 articles.

1. Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma;Vaupel;Cancer Res,1981

2. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors;Vaupel;Cancer Res,1989

3. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects;Höckel;J Natl Cancer Inst,2001

4. Hypoxic gene expression and metastasis;Le;Cancer Metastasis Rev,2004

5. Hypoxia, DNA repair and genetic instability;Bristow;Nature,2008

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