Structural and energetic analysis to provide insight residues of CYP2C9, 2C11 and 2E1 involved in valproic acid dehydrogenation selectivity

Author:

Bello Martiniano,Mendieta-Wejebe Jessica E.,Correa-Basurto José

Funder

Consejo Nacional de Ciencia y Tecnología

Instituto de Ciencia y Tecnología del Distrito Federal

Secretaría de Investigación y Posgrado/Comisión de Operación y Fomento de Actividades Académicas del Instituto Politécnico Nacional

CONACyT

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference94 articles.

1. Valproate: past, present and future;Johannessen;CNS Drug Rev,2003

2. Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective;Tang;Drug Metab Rev,2010

3. Drug metabolite profiling and elucidation of drug-induced hepatotoxicity;Tang;Expert Opin Drug Metab Toxicol,2007

4. The covalent binding to protein of valproic acid and its hepatotoxic metabolite, 2-n-propyl-4-pentenoic acid, in rats and in isolated rat hepatocytes;Porubek;Drug Metab Dispos,1989

5. Evaluation of felbamate and other antiepileptic drug toxicity potential based on hepatic protein covalent binding and gene expression;Leone;Chem Res Toxicol,2007

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