Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells

Author:

Wiśniewska Anita,Niemira Magdalena,Jagiełło Karolina,Potęga Agnieszka,Świst Małgorzata,Henderson Colin,Skwarska Anna,Augustin Ewa,Konopa Jerzy,Mazerska Zofia

Funder

Ministry of Science and Higher Education (Poland)

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference35 articles.

1. Konopa J, Wysocka-Skrzela B, Tiwari RK. 9-Alkilamino-1-nitroacridine derivatives, European patent, 01910914.9-2101-US0105199 (1981), American patent, 6.589.961 B2.

2. Antitumor 1-nitroacridine derivative C-1748, induces apoptosis, necrosis or senescence in human colon carcinoma HCT8 and HT29 cells;Augustin;Biochem Pharmacol,2010

3. Preclinical studies of 1-nitroacridines derivatives: effective anti-tumor agents for prostate cells;Chen;Proc Am Assoc Cancer Res,2002

4. Induction of androgen receptor by a novel nitroacridine, C-1748: implication for its role as a chemotherapeutic agent in hormone independent prostate cancer;Tadi;Proc Am Assoc Cancer Res,2005

5. Pre-clinical evaluation of 1-nitroacridine derived chemotherapeutic agent that has preferential cytotoxic activity towards prostate cancer;Tadi;Cancer Biol,2007

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