Synthesis, pharmacological evaluation and Molecular modelling studies of pregnenolone derivatives as inhibitors of human dihydrofolate reductase-Reference-Cited by-同舟云学术

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Synthesis, pharmacological evaluation and Molecular modelling studies of pregnenolone derivatives as inhibitors of human dihydrofolate reductase

Published:2021-04 Issue: Volume:168 Page:108801
ISSN:0039-128X
Container-title:Steroids
language:en
Short-container-title:Steroids

Author:

Bilal Tufail Muhammad,Aamir Javed Muhammad,Ikram Muhammad,Mahnashi Mater H.,Alyami Bandar A.,Alqahtani Yahya S.,Sadiq Abdul,Rashid Umer

Funder

Higher Education Commission, Pakistan

Najran University

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Pharmacology,Endocrinology,Molecular Biology,Biochemistry

Reference28 articles.

1. Cancer economics, policy and politics: what informs the debate? Perspectives from the EU, Canada and US;Aggarwal;J. Cancer Policy,2014

2. Cancer statistics;Siegel;CA Cancer J. Clin.,2020

3. Dihydrofolate reductase as a therapeutic target;Schweitzer;FASEB J.,1990

4. Structural characteristics of antifolate dihydrofolate reductase enzyme interactions;Vivian;Crystallogr. Rev.,2006

5. Mechanism inspired development of rationally designed dihydrofolate reductase inhibitors as anticancer agents;Singh;J. Med. Chem.,2012

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1. Pregnenolone derivatives for the treatment of Alzheimer's disease: synthesis, and in vitro inhibition of amyloid β_1–42 peptide aggregation, acetylcholinesterase and carbonic anhydrase-II;RSC Advances;2024

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4. Novel Glu-based pyrazolo[3,4-d]pyrimidine analogues: design, synthesis and biological evaluation as DHFR and TS dual inhibitors;Journal of Enzyme Inhibition and Medicinal Chemistry;2023-04-20

5. New thiazole-based derivatives as EGFR/HER2 and DHFR inhibitors: Synthesis, molecular modeling simulations and anticancer activity;European Journal of Medicinal Chemistry;2022-11

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