Luteolin attenuates lipopolysaccharide-induced acute lung injury/acute respiratory distress syndrome by activating alveolar epithelial sodium channels via cGMP/PI3K pathway

Author:

Hou Yapeng,Li Jun,Ding Yan,Cui YongORCID,Nie HongguangORCID

Funder

National Natural Science Foundation of China

Southwest Medical University

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology

Reference45 articles.

1. Transepithelial fluid and salt re-absorption regulated by cGK2 signals;Chang;Int. J. Mol. Sci.,2018

2. Epithelial sodium channel enhanced osteogenesis via cGMP/PKGII/ENaC signaling in rat osteoblast;Chen;Mol. Biol. Rep.,2014

3. Formaldehyde impairs transepithelial sodium transport;Cui;Sci. Rep.,2016

4. Depletion of cyclic-GMP levels and inhibition of cGMP-dependent protein kinase activate p21(Cip 1)/p27(Kip 1) pathways and lead to renal fibrosis and dysfunction;Das;Faseb. J.,2020

5. Insulin ameliorates pulmonary edema through the upregulation of epithelial sodium channel via the PI3K/SGK1 pathway in mice with lipopolysaccharide-induced lung injury;Deng;Mol. Med. Rep.,2019

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