Comparison of rat dopamine D2 receptor occupancy for a series of antipsychotic drugs measured using radiolabeled or nonlabeled raclopride tracer

Author:

Barth Vanessa N.,Chernet Eyassu,Martin Laura J.,Need Anne B.,Rash Karen S.,Morin Michelle,Phebus Lee A.

Publisher

Elsevier BV

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference19 articles.

1. Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: resistance to differential rearing conditions;Bardo;Neuroscience,1991

2. Quantitative autoradiographic localization of the D1 and D2 subtypes of dopamine receptors in rat brain;Boyson;Journal of Neuroscience,1986

3. Use of LC/MS to assess brain tracer distribution in preclinical, in vivo receptor occupancy studies: dopamine D2, serotonin 2A and NK-1 receptors as examples;Chernet;Life Sciences,2005

4. Dopamine D2 receptors labeled with [3H]raclopride in rat and rabbit brains. Equilibrium binding, kinetics, distribution and selectivity;Dewar;Journal of Pharmacology and Experimental Therapeutics,1989

5. Central D2-dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs;Farde;Archives of General Psychiatry,1988

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