Regulation of Keap-1/Nrf2/AKT and iNOS/NF-κB/TLR4 signals by apocynin abrogated methotrexate-induced testicular toxicity: Mechanistic insights and computational pharmacological analysis

Author:

Sayed Ahmed M.,Hassanein Emad H.M.,Ali Fares E.M.,Omar Zainab M.M.,Rashwan Eman K.,Mohammedsaleh Zuhair M.,Abd El-Ghafar Omnia A.M.

Funder

Faculty of Veterinary Medicine, Cairo University

Publisher

Elsevier BV

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference69 articles.

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3. Methotrexate overdose in clinical practice;Pannu;Curr. Drug Metab.,2019

4. Light and electron microscope examination of the effects of methotrexate on the endosalpinx;Bayram;Eur. J. Obstet. Gynecol. Reprod. Biol.,2005

5. Protective effects of carvacrol against methotrexate-induced testicular toxicity in rats;Daggulli;Int. J. Clin. Exp. Med.,2014

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