Pargyline-induced hepatotoxicity: Possible mediation by the reactive metabolite, propiolaldehyde

Author:

DeMaster Eugene G.,Sumner Hatton W.,Kaplan Eli,Shirota Frances N.,Nagasawa Herbert T.

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference29 articles.

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2. Biotransformation and hepatotoxicity of halothane;Brown;Biochem. Pharmacol.,1977

3. Glutathione alterations in rat liver after acute and subacute oral administration of paracetamol;Buttar;Clin. Exp. Pharmacol. Physiol.,1977

4. The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents;Chasseaud,1979

5. Microsomal N-depropargylation of pargyline to propiolaldehyde, an irreversible inhibitor of mitochondrial aldehyde dehydrogenase;DeMaster;Advan. Exp. Med. Biol.,1980

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