Improving the Accuracy of Predicted Human Pharmacokinetics: Lessons Learned from the AstraZeneca Drug Pipeline Over Two Decades
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Published:2020-06
Issue:6
Volume:41
Page:390-408
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ISSN:0165-6147
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Container-title:Trends in Pharmacological Sciences
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language:en
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Short-container-title:Trends in Pharmacological Sciences
Author:
Davies MichaelORCID,
Jones Rhys D.O.,
Grime Ken,
Jansson-Löfmark Rasmus,
Fretland Adrian J.,
Winiwarter Susanne,
Morgan Paul,
McGinnity Dermot F.
Subject
Pharmacology,Toxicology
Reference75 articles.
1. The state of innovation in drug development;Kola;Clin. Pharmacol. Ther.,2008
2. The impact of in vitro binding on in vitro-in vivo extrapolations, projections of metabolic clearance and clinical drug-drug interactions;Grime;Curr. Drug Metab.,2006
3. A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes;Riley;Drug Metab. Dispos.,2005
4. PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: comparative assessement of prediction methods of human clearance;Ring;J. Pharm. Sci.,2011
5. PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 1: goals, properties of the PhRMA dataset, and comparison with literature datasets;Poulin;J. Pharm. Sci.,2011
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