Human aortic valve interstitial cells obtained from patients with aortic valve stenosis are vascular endothelial growth factor receptor 2 positive and contribute to ectopic calcification

Author:

Liu Xu,Yu Zaiqiang,Daitoku Kazuyuki,Fukuda Ikuo,Motomura Shigeru,Matsumiya Tomoh,Imaizumi Tadaatsu,Furukawa Ken-Ichi,Seya Kazuhiko

Funder

Japan Society for the Promotion of Science

Publisher

Elsevier BV

Subject

Pharmacology,Molecular Medicine

Reference23 articles.

1. Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly;Otto;N Engl J Med,1999

2. Tumor necrosis factor alpha promotes an osteoblast-like phenotype in human aortic valve myofibroblasts: a potential regulatory mechanism of valvular calcification;Kaden;Int J Mol Med,2005

3. Therapeutic decisions for patients with symptomatic severe aortic stenosis: room for improvement?;van Geldorp;Eur J Cardio Thorac Surg,2009

4. Progression of aortic valve stenosis: TGF-beta 1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis;Jian;Ann Thorac Surg,2003

5. Interleukin-1 beta promotes matrix metalloproteinase expression and cell proliferation in calcific aortic valve stenosis;Kaden;Atherosclerosis,2003

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