The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512

Author:

Mziaut HassanORCID,Mulligan Bernard,Hoboth Peter,Otto Oliver,Ivanova Anna,Herbig Maik,Schumann DesireeORCID,Hildebrandt Tobias,Dehghany JaberORCID,Sönmez Anke,Münster Carla,Meyer-Hermann MichaelORCID,Guck Jochen,Kalaidzidis Yannis,Solimena MicheleORCID

Funder

Boeringher Ingelheim

German Center for Diabetes Research

German Network of Diabetes Competence

German Ministry for Education and Research

Innovative Medicines Initiative Joint Undertaking

European Union's Seventh Framework Program

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology

Reference50 articles.

1. Studies on the secretion of newly synthesized proinsulin and insulin from isolated rat islets of Langerhan;Sando;Journal of Clinical Investigation,1972

2. Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies;Hoboth;Proceedings of the National Academy of Sciences United States of America,2015

3. Destabilization of actin filaments as a requirement for the secretion of catecholamines from permeabilized chromaffin cells;Lelkes;FEBS Letters,1986

4. Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells;Muallem;Journal of Cell Biology,1995

5. Secretion from permeabilised mast cells is enhanced by addition of gelsolin: contrasting effects of endogenous gelsolin;Borovikov;Journal of Cell Science,1995

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